Baked clay pellets, also known under the trademarks 'Hydroton' or 'Hydrokorrels' or 'LECA' ("lightweight expanded clay aggregate"), are suitable for hydroponic systems in which all nutrients are carefully controlled in water solution. The clay pellets are inert, pH neutral and do not contain any nutrient value.

The clay is formed into round pellets and fired in rotary kilns at 1,200 °C (2,190 °F). This causes the clay to expand, like popcorn, and become porous. It is light in weight, and does not compact over time. The shape of an individual pellet can be irregular or uniform depending on brand and manufacturing process. The manufacturers consider expanded clay to be an ecologically sustainable and re-usable growing medium because of its ability to be cleaned and sterilized, typically by washing in solutions of white vinegar, chlorine bleach, or hydrogen peroxide (H2O2), and rinsing completely.

Another view is that clay pebbles are best not re-used even when they are cleaned, due to root growth that may enter the medium. Breaking open a clay pebble after a crop has been grown will reveal this growth.

Rockwool (mineral wool) is the most widely used medium in hydroponics. Rockwool is an inert substrate suitable for both run to waste and recirculating systems. Rock wool is made from molten rock, basalt or 'slag' that is spun into bundles of single filament fibres, and bonded into a medium capable of capillary action, and are in effect protected from most common microbiological degradation. Rockwool has many advantages and disadvantages. Advantages include its proven efficiency and effectiveness as a commercial hydroponic substrate. Disadvantages include its classification as a possible carcinogen.

Coco Peat, also known as coir or coco, is the leftover material after the fibres have been removed from the outermost shell (bolster) of the coconut. Coir is a 100% natural grow and flowering medium. Coconut Coir is colonized with trichoderma Fungi, which protects roots and stimulates root growth. It is extremely difficult to over water coir due to its perfect air-to-water ratio, plant roots thrive in this environment, coir has a high cation exchange, meaning it can store unused minerals to be released to the plant as and when it requires it. Coir is available in many forms, most common is coco peat, which has the appearance and texture of soil but contains no mineral content.

Perlite is a volcanic rock that has been superheated into very lightweight expanded glass pebbles. It is used loose or in plastic sleeves immersed in the water. It is also used in potting soil mixes to decrease soil density. Perlite has similar properties and uses to vermiculite but, in general, holds more air and less water. If not contained, it can float if flood and drain feeding is used. It is a fusion of granite, obsidian, pumice and basalt. This volcanic rock is naturally fused at high temperatures undergoing what is called "Fusionic Metamorphosis".

Like perlite, vermiculite is a mineral that has been superheated until it has expanded into light pebbles. Vermiculite holds more water than perlite and has a natural "wicking" property that can draw water and nutrients in a passive hydroponic system. If too much water and not enough air surrounds the plants roots, it is possible to gradually lower the medium's water-retention capability by mixing in increasing quantities of perlite.

Sand is cheap and easily available. However, it is heavy, does not hold water very well, and it must be sterilized between use.

The same type that is used in aquariums, though any small gravel can be used, provided it is washed first. Indeed, plants growing in a typical traditional gravel filter bed, with water circulated using electric powerhead pumps, are in effect being grown using gravel hydroponics. Gravel is inexpensive, easy to keep clean, drains well and will not become waterlogged. However, it is also heavy, and, if the system does not provide continuous water, the plant roots may dry out

Aeroponics is the process of growing plants in an air or mist environment without the use of soil or an aggregate medium (known as geoponics). The word "aeroponic" is derived from the Greek meanings of aero- (air) and ponos (labour). Aeroponic culture differs from both conventional hydroponics and in-vitro (plant tissue culture) growing. Unlike hydroponics, which uses water as a growing medium and essential minerals to sustain plant growth, aeroponics is conducted without a growing medium. Because water is used in aeroponics to transmit nutrients, it is sometimes considered a type of hydroponics.

Aquaponics is a sustainable food production system that combines a traditional aquaculture (raising aquatic animals such as fish, crayfish or prawns in tanks) with hydroponics (cultivating plants in water) in a symbiotic environment. In the aquaculture, effluents accumulate in the water, increasing toxicity for the fish. This water is led to a hydroponic system where the by-products from the aquaculture are filtered out by the plants as vital nutrients, after which the cleansed water is recirculated back to the animals. The term aquaponics is a portmanteau of the terms aquaculture and hydroponic.

Aquaponic systems vary in size from small indoor or outdoor units to large commercial units, using the same technology. The systems usually contain fresh water, but salt water systems are plausible depending on the type of aquatic animal and which plants. Aquaponic science may still be considered to be at an early stage